Sep 20, 2017

Methylome underpins differentiation potential of neural stem and progenitor cells
Published in Cell Reports

Using freshly isolated neural stem/progenitor cells from mouse embryonic brain, our member Drs. Imamura and Nakashima together with colleagues revealed sequential changes in genome-wide DNA methylation status in the developing mouse CNS. This resource characterizes stage-dependent differentially methylation regions (DMRs), targeted by specific transcription factors including NFI, for the understanding of cell-intrinsic mechanisms in the CNS.

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Tsukasa Sanosaka* Takuya Imamura* Nobuhiko Hamazaki, MuhChyi Chai, Katsuhide Igarashi, Maky Ideta-Otsuka, Fumihito Miura, Takashi Ito, Nobuyuki Fujii, Kazuho Ikeo, and Kinichi Nakashima*

DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells
Cell Reports 20, 2992–3003, September 19, 2017