- Methylome underpins differentiation potential of neural stem and progenitor cells
Sep 20, 2017
Methylome underpins differentiation potential of neural stem and progenitor cells
Published in Cell Reports
Using freshly isolated neural stem/progenitor cells from mouse embryonic brain, our member Drs. Imamura and Nakashima together with colleagues revealed sequential changes in genome-wide DNA methylation status in the developing mouse CNS. This resource characterizes stage-dependent differentially methylation regions (DMRs), targeted by specific transcription factors including NFI, for the understanding of cell-intrinsic mechanisms in the CNS.
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Tsukasa Sanosaka* Takuya Imamura* Nobuhiko Hamazaki, MuhChyi Chai, Katsuhide Igarashi, Maky Ideta-Otsuka, Fumihito Miura, Takashi Ito, Nobuyuki Fujii, Kazuho Ikeo, and Kinichi Nakashima*
DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells
Cell Reports 20, 2992–3003, September 19, 2017