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Sep 9, 2021

Achievement over 5 years since 2028
May 26, 2021

MeCP2 controls neural stem cell fate specificationthrough miR-199a-mediated inhibition of BMP-Smadsignaling
Published in Cell Reports
Mar 24, 2021

Prefrontal synaptic transmission associated with hippocampal neuronal memory reactivation
Published in Cell Reports
Jan 8, 2021

Paternal age affects offspring via an epigenetic mechanism
Dec 16, 2020

Hippocampal neurons replay learning-related episodes
Published in Proceedings of the National Academy of Sciences of the United States of America
Sep 17, 2020

Optimization of light-inducible Gal4/UAS gene expression system in mammalian cells
Sep 15, 2020

Elucidating the mechanisms for newborn neurons' departure ~ The DSCAM protein slices off the legs of the neurons attached to the ventricular surface. ~
The study by Hoshino's group (A02) has been published in Science Advances
Aug 3, 2020

The Shibata Project Group of A03 has published a model for DeepLabCut, which enables the world's first estimation of macaque monkeys' motions in the natural environment from 2D images
Jul 2, 2020

AUTS2 gene, which is related to a variety of psychiatric disorders regulates synapse homeostasis
Mar 16, 2020

Love hormone influences medaka’s mate preference: oxytocin works in a sex-specific manner
Published in Proceedings of the National Academy of Sciences
Mar 10, 2020

Principal investigators, Takanobu Nakazawa (A01) and Kaoru Seiriki (A03) published the Nature Communications paper reporting that ASD-associated de novo mutations on the POGZ gene impair cortical development and reversible autism-like phenotypes in mice.
Feb 21,2020

The difficulty with sports in individuals with autism spectrum disorder may be caused by impairment in tool–body assimilation
Dec 19, 2019

The role of the hippocampal biological clock in the control of memory recall and its molecular mechanism
A paper by the Principal Investigator (A01), Satoshi Kida, has been published in Nature Communications.
Dec 2, 2019

Evolutionary changes in neurotransmitter uptake of VMAT1, possibly having made us prone to anxiety
Published in BMC Evolutionary Biology
Jul 23, 2019

Neuronal mechanisms to account for individual differences in psychiatric stress-induced physiological dysfunctions
May 1, 2019

High Hes1 expression and resultant Ascl1 suppression regulate quiescent versus active neural stem cells in the adult mouse brain.
Jan 16, 2019

Direct reprogramming of microglia into functional neurons by a single transcription factor, NeuroD1
Published in Neuron
Oct 20, 2018

The data sharing platform was released.
Oct 17, 2018

Light-inducible Tet-gene expression system in mammalian cells.
Aug 6, 2018

The evolutionary trajectory of spatial transcriptome and epigenome in primate brains
Published in Genome Research
Jul 30, 2018

Auditory-independent repeatability in the generation of an individually unique, species-specific song structure in songbird, canary
Published in Scientific Reports
Jul 9, 2018

Forebrain Ptf1a is required for sexual differentiation of the brain
Published in Cell Reports
Apr 5, 2018

Prenatal exposure to an antiepileptic drug increased seizure susceptibility in adult mice
Published in Proc Natl Acad Sci USA
Mar 23, 2018

A cancer-related gene, Meis1, regulates cerebellar development
Published in Journal of Neuroscience
Mar 16, 2018

Adult-born neurons facilitate olfactory bulb pattern separation during task engagement.
Jan 16, 2018

Hippocampal neuronal network supports spatial working memory and encodes future events
Published in Nature Neuroscience
Nov 2, 2017

Direct estimation of de novo mutation rates in a chimpanzee parent-offspring trio by ultra-deep whole-genome sequencing.
Published in Scientific Reports.
Nov 2, 2017

How far did you fall from the tree?
The paper "Direct estimation of de novo mutation rates in a chimpanzee parent-offspring trio by ultra-deep whole genome sequencing" appeared 1 November 2017 in Scientific Reports
Sep 20, 2017

Methylome underpins differentiation potential of neural stem and progenitor cells
Published in Cell Reports
Jul 27, 2017

Itaru Imayoshi
The First Awardee of the Altman Award in Developmental Neuroscience
Jun 9, 2017

Hypoxia epigenetically confers astrocytic differentiation potential on human pluripotent cell-derived neural precursor cells
Jun 9, 2017

Hypoxia-induced DNA demethylation allows Human Pluripotent Cell-Derived Neural Precursor Cells to differentiate into astrocytes
Published in Stem Cell Reports
Nov 18, 2016

Paternal aging and its possible link to neurodevelopmental disorders
Published in PLoS ONE
Oct 7, 2016

Single-neuron and genetic correlates of autistic behavior in macaque
Published in Science Advances

Scientific Research on
Innovative Areas FY2016-2020Brain and Individuality

Activities

Achievement over 5 years since 2028

MeCP2 controls neural stem cell fate specificationthrough miR-199a-mediated inhibition of BMP-Smadsignaling
Published in Cell Reports

Prefrontal synaptic transmission associated with hippocampal neuronal memory reactivation
Published in Cell Reports

Paternal age affects offspring via an epigenetic mechanism

Hippocampal neurons replay learning-related episodes
Published in Proceedings of the National Academy of Sciences of the United States of America

Optimization of light-inducible Gal4/UAS gene expression system in mammalian cells

Elucidating the mechanisms for newborn neurons' departure ~ The DSCAM protein slices off the legs of the neurons attached to the ventricular surface. ~
The study by Hoshino's group (A02) has been published in Science Advances

The Shibata Project Group of A03 has published a model for DeepLabCut, which enables the world's first estimation of macaque monkeys' motions in the natural environment from 2D images

AUTS2 gene, which is related to a variety of psychiatric disorders regulates synapse homeostasis

Love hormone influences medaka’s mate preference: oxytocin works in a sex-specific manner
Published in Proceedings of the National Academy of Sciences

Principal investigators, Takanobu Nakazawa (A01) and Kaoru Seiriki (A03) published the Nature Communications paper reporting that ASD-associated de novo mutations on the POGZ gene impair cortical development and reversible autism-like phenotypes in mice.

The difficulty with sports in individuals with autism spectrum disorder may be caused by impairment in tool–body assimilation

The role of the hippocampal biological clock in the control of memory recall and its molecular mechanism
A paper by the Principal Investigator (A01), Satoshi Kida, has been published in Nature Communications.

Evolutionary changes in neurotransmitter uptake of VMAT1, possibly having made us prone to anxiety
Published in BMC Evolutionary Biology

Neuronal mechanisms to account for individual differences in psychiatric stress-induced physiological dysfunctions

High Hes1 expression and resultant Ascl1 suppression regulate quiescent versus active neural stem cells in the adult mouse brain.

Direct reprogramming of microglia into functional neurons by a single transcription factor, NeuroD1
Published in Neuron

The data sharing platform was released.

Light-inducible Tet-gene expression system in mammalian cells.

The evolutionary trajectory of spatial transcriptome and epigenome in primate brains
Published in Genome Research

Auditory-independent repeatability in the generation of an individually unique, species-specific song structure in songbird, canary
Published in Scientific Reports

Forebrain Ptf1a is required for sexual differentiation of the brain
Published in Cell Reports

Prenatal exposure to an antiepileptic drug increased seizure susceptibility in adult mice
Published in Proc Natl Acad Sci USA

A cancer-related gene, Meis1, regulates cerebellar development
Published in Journal of Neuroscience

Adult-born neurons facilitate olfactory bulb pattern separation during task engagement.

Hippocampal neuronal network supports spatial working memory and encodes future events
Published in Nature Neuroscience

Direct estimation of de novo mutation rates in a chimpanzee parent-offspring trio by ultra-deep whole-genome sequencing.
Published in Scientific Reports.

How far did you fall from the tree?
The paper "Direct estimation of de novo mutation rates in a chimpanzee parent-offspring trio by ultra-deep whole genome sequencing" appeared 1 November 2017 in Scientific Reports

Methylome underpins differentiation potential of neural stem and progenitor cells
Published in Cell Reports

Itaru Imayoshi
The First Awardee of the Altman Award in Developmental Neuroscience

Hypoxia epigenetically confers astrocytic differentiation potential on human pluripotent cell-derived neural precursor cells

Hypoxia-induced DNA demethylation allows Human Pluripotent Cell-Derived Neural Precursor Cells to differentiate into astrocytes
Published in Stem Cell Reports

Paternal aging and its possible link to neurodevelopmental disorders
Published in PLoS ONE

Single-neuron and genetic correlates of autistic behavior in macaque
Published in Science Advances