Jan 8, 2021

Paternal age affects offspring via an epigenetic mechanism

Osumi Group has revealed a mechanism associated with an increased risk of behavioral defects among offspring of aged fathers in a mouse study. We examined the link between behavioral defects in mice, specifically animal communication, and decrease of DNA methylation - a major process controlling the expression of genes with a critical role in cell development, ageing and diseases such as cancer.

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Published in EMBO Reports