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Jan 8, 2021

Paternal age affects offspring via an epigenetic mechanism

Osumi Group has revealed a mechanism associated with an increased risk of behavioral defects among offspring of aged fathers in a mouse study. We examined the link between behavioral defects in mice, specifically animal communication, and decrease of DNA methylation - a major process controlling the expression of genes with a critical role in cell development, ageing and diseases such as cancer.

Press Release:

https://www.tohoku.ac.jp/en/press/age_father_affects_offspring_epigenetic_mechanism.html

EMBO Press Release:

https://www.embo.org/news/press-releases/2021/age-of-father-affects-offspring-through-an-epigenetic-mechanism.html

Article:

https://www.embopress.org/doi/full/10.15252/embr.202051524

Published in EMBO Reports

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