Scientific Research on
Innovative Areas FY2016-2020Brain and Individuality

Sep 9, 2021Release

Achievement over 5 years since 2028

May 26, 2021Release

MeCP2 controls neural stem cell fate specificationthrough miR-199a-mediated inhibition of BMP-Smadsignaling

Published in Cell Reports

Mar 24, 2021Release

Prefrontal synaptic transmission associated with hippocampal neuronal memory reactivation

Published in Cell Reports

Jan 8, 2021Release

Paternal age affects offspring via an epigenetic mechanism

Dec 16, 2020Release

Hippocampal neurons replay learning-related episodes

Published in Proceedings of the National Academy of Sciences of the United States of America

Sep 17, 2020Release

Optimization of light-inducible Gal4/UAS gene expression system in mammalian cells

Sep 15, 2020Release

Elucidating the mechanisms for newborn neurons' departure ~ The DSCAM protein slices off the legs of the neurons attached to the ventricular surface. ~

The study by Hoshino's group (A02) has been published in Science Advances

Aug 3, 2020Release

The Shibata Project Group of A03 has published a model for DeepLabCut, which enables the world's first estimation of macaque monkeys' motions in the natural environment from 2D images

AUTS2 gene, which is related to a variety of psychiatric disorders regulates synapse homeostasis

Mar 16, 2020Release

Love hormone influences medaka’s mate preference: oxytocin works in a sex-specific manner
Published in Proceedings of the National Academy of Sciences

Mar 10, 2020Release

Principal investigators, Takanobu Nakazawa (A01) and Kaoru Seiriki (A03) published the Nature Communications paper reporting that ASD-associated de novo mutations on the POGZ gene impair cortical development and reversible autism-like phenotypes in mice.

Feb 21,2020Release

The difficulty with sports in individuals with autism spectrum disorder may be caused by impairment in tool–body assimilation

Dec 19, 2019Release

The role of the hippocampal biological clock in the control of memory recall and its molecular mechanism
A paper by the Principal Investigator (A01), Satoshi Kida, has been published in Nature Communications.

Dec 2, 2019Release

Evolutionary changes in neurotransmitter uptake of VMAT1, possibly having made us prone to anxiety

Published in BMC Evolutionary Biology

Jul 23, 2019Release

Neuronal mechanisms to account for individual differences in psychiatric stress-induced physiological dysfunctions

May 1, 2019Release

High Hes1 expression and resultant Ascl1 suppression regulate quiescent versus active neural stem cells in the adult mouse brain.

Jan 16, 2019Release

Direct reprogramming of microglia into functional neurons by a single transcription factor, NeuroD1

Published in Neuron

Oct 20, 2018Release

The data sharing platform was released.

Oct 17, 2018Release

Light-inducible Tet-gene expression system in mammalian cells.

Aug 6, 2018Release

The evolutionary trajectory of spatial transcriptome and epigenome in primate brains

Published in Genome Research

Jul 30, 2018Release

Auditory-independent repeatability in the generation of an individually unique, species-specific song structure in songbird, canary

Published in Scientific Reports

Jul 9, 2018Release

Forebrain Ptf1a is required for sexual differentiation of the brain

Published in Cell Reports

Apr 5, 2018Release

Prenatal exposure to an antiepileptic drug increased seizure susceptibility in adult mice

Published in Proc Natl Acad Sci USA

Mar 16, 2018Release

Adult-born neurons facilitate olfactory bulb pattern separation during task engagement.

Mar 23, 2018Release

A cancer-related gene, Meis1, regulates cerebellar development

Published in Journal of Neuroscience

Jan 16, 2018Release

Hippocampal neuronal network supports spatial working memory and encodes future events

Published in Nature Neuroscience

Nov 2, 2017Release

Direct estimation of de novo mutation rates in a chimpanzee parent-offspring trio by ultra-deep whole-genome sequencing.

Published in Scientific Reports.

Nov 2, 2017Release

How far did you fall from the tree?

The paper "Direct estimation of de novo mutation rates in a chimpanzee parent-offspring trio by ultra-deep whole genome sequencing" appeared 1 November 2017 in Scientific Reports

Sep 20, 2017Release

Methylome underpins differentiation potential of neural stem and progenitor cells

Published in Cell Reports

Jul 27, 2017Release

Itaru Imayoshi
The First Awardee of the Altman Award in Developmental Neuroscience

Jun 9, 2017Release

Hypoxia epigenetically confers astrocytic differentiation potential on human pluripotent cell-derived neural precursor cells

Jun 9, 2017Release

Hypoxia-induced DNA demethylation allows Human Pluripotent Cell-Derived Neural Precursor Cells to differentiate into astrocytes

Published in Stem Cell Reports

Nov 18, 2016Release

Paternal aging and its possible link to neurodevelopmental disorders

Published in PLoS ONE

Oct 7, 2016Release

Single-neuron and genetic correlates of autistic behavior in macaque

Published in Science Advances