- Prenatal exposure to an antiepileptic drug increased seizure susceptibility in adult mice
Apr 5, 2018
Prenatal exposure to an antiepileptic drug increased seizure susceptibility in adult mice
Published in Proc Natl Acad Sci USA
Recent clinical studies suggest that environmental insults, such as valproic acid (VPA) exposure, in utero can have adverse effects on brain function of the offspring in later life. By focusing on the property of neural stem/progenitor cells (NS/PCs) residing in the adult hippocampus, we identified the mechanism of increased seizure sensitivity in prenatally VPA-exposed adult mice. Furthermore, we found that voluntary exercise can overcome the adverse effects through normalizing VPA-induced transcriptome alterations in NS/PCs.
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Atsuhiko Sakai, Taito Matsuda, Hiroyoshi Doi, Yukiko Nagaishi, Kiyoko Kato, and Kinichi Nakashima
Ectopic neurogenesis induced by prenatal antiepileptic drug exposure augments seizure susceptibility in adult mice
Proc Natl Acad Sci USA. 115, 4270-4275, 2018.