Jul 9, 2018
Forebrain Ptf1a is required for sexual differentiation of the brain
Published in Cell Reports
The mammalian brain undergoes sexual differentiation by gonadal hormones during the perinatal critical period. However, the machinery at earlier stages has not been well studied. Our members, Mikio Hoshino, Tomoyuki Fujiyama and colleagues at National Center of Neurology and Psychiatry (NCNP) revealed that (1) embryonic brains have to acquire the "sex differentiation competence" before the critical period for proper sexual differentiation and (2) Ptf1a expression in the embryonic forebrain is required for its acquisition. This is the collaborative work with Prof. Yanagisawa/Funato Lab at Tsukuba Univ and Dr. Tsuoneoka at Toho Univ.
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Forebrain Ptf1a is required for sexual differentiation of the brain.
Fujiyama T, Miyashita S, Tsuneoka Y, Kanemaru K, Kakizaki M, Kanno S, Ishikawa Y, Yamashita M, Owa T, Nagaoka M, Kawaguchi Y, Yanagawa Y, Magnuson MA, Shibuya A, Nabeshima Y, Yanagisawa M, Funato H, Hoshino M:
Cell Reports, 24, 79-94, 2018